Differential drug resistance acquisition in HIV-1 of subtypes B and C.

ABSTRACT:

Background

Subtype C is the most prevalent HIV-1 subtype in the world, mainly in countries with the highest HIV prevalence. However, few studies have evaluated the impact of antiretroviral therapy on this subtype. In southern Brazil, the first developing country to offer free and universal treatment, subtypes B and C co-circulate with equal prevalence, allowing for an extensive evaluation of this issue.

Methods and findings

Viral RNA of 160 HIV-1+ patients was extracted, and the protease and reverse transcriptase genes were sequenced, subtyped and analyzed for ARV mutations. Sequences were grouped by subtype, and matched to type (PI, NRTI and NNRTI) and time of ARV exposure. Statistical analyses were performed to compare differences in the frequency of ARV-associated mutatio

SUBMITTER: Soares EA 

PROVIDER: S-EPMC1939879 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature