Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica.

ABSTRACT:

Background

Histone modification regulates chromatin structure and influences gene expression associated with diverse biological functions including cellular differentiation, cancer, maintenance of genome architecture, and pathogen virulence. In Entamoeba, a deep-branching eukaryote, short chain fatty acids (SCFA) affect histone acetylation and parasite development. Additionally, a number of active histone modifying enzymes have been identified in the parasite genome. However, the overall extent of gene regulation tied to histone acetylation is not known.

Results

In order to identify the genome-wide effects of histone acetylation in regulating E. histolytica gene expression, we used whole-genome expression profiling of parasites treated with SCFA and Trichostatin A (TSA). Des

SUBMITTER: Ehrenkaufer GM 

PROVIDER: S-EPMC1940012 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature