Reuse of structural domain-domain interactions in protein networks.

ABSTRACT:

Background

Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures to known domain families. Here, we investigate how the domain interactions from the iPfam database are distributed in protein interactions taken from the HPRD, MPact, BioGRID, DIP and IntAct databases.

Results

We find that known structural domain interactions can only explain a subset of 4-19% of the available protein interactions, nevertheless this fraction is still significantly bigger than expected by chance. There is a correlation between the frequency of a domain interaction and the connectivity of the proteins it occurs in. Furthermore, a large proportion of protein interactions can be attribute

SUBMITTER: Schuster-Bockler B 

PROVIDER: S-EPMC1940023 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature