Ontology highlight
ABSTRACT:
SUBMITTER: Sipos L
PROVIDER: S-EPMC1941339 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Sipos László L Kozma Gabriella G Molnár Eniko E Bender Welcome W
Proceedings of the National Academy of Sciences of the United States of America 20070718 30
Genes of the Polycomb group maintain long-term, segment-specific repression of the homeotic genes in Drosophila. DNA targets of Polycomb group proteins, called Polycomb response elements (PREs), have been defined by several assays, but they have not been dissected in their original chromosomal context. An enhanced method of gene conversion was developed to generate a series of small, targeted deletions encompassing the best-studied PRE, upstream of the Ultrabithorax (Ubx) transcription unit in t ...[more]