Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis.

ABSTRACT: Knowledge about the in vivo role of endothelium in chronic human atherosclerosis has mostly been derived by insights from mouse models. Therefore, we set out to establish by microarray analyses the gene expression profiles of endothelium from human large arteries, as isolated by laser microbeam microdissection, having focal atherosclerosis of the early or the advanced stage. Within individual arteries, the endothelial transcriptomes of the lesional and unaffected sides were compared pairwise, thus limiting genetic and environmental confounders. Specific endothelial signature gene sets were identified with changed expression levels in either early (n = 718) or advanced atherosclerosis (n = 403), relative to their paired plaque-free controls. Gene set enrichment analysis identified distinct

SUBMITTER: Volger OL 

PROVIDER: S-EPMC1941599 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature