Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis.

ABSTRACT:

Background

Alternative promoters usage is an important paradigm in transcriptional control of mammalian gene expression. However, despite the growing interest in alternative promoters and their role in genome diversification, very little is known about how and on what occasions those promoters are differentially regulated. Runx1 transcription factor is a key regulator of early hematopoiesis and a frequent target of chromosomal translocations in acute leukemias. Mice deficient in Runx1 lack definitive hematopoiesis and die in mid-gestation. Expression of Runx1 is regulated by two functionally distinct promoters designated P1 and P2. Differential usage of these two promoters creates diversity in distribution and protein-coding potential of the mRNA transcripts. While the alternative

SUBMITTER: Pozner A 

PROVIDER: S-EPMC1941738 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature