Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes.

ABSTRACT: Geographic partitioning is postulated to foster divergence of Helicobacter pylori populations as an adaptive response to local differences in predominant host physiology. H. pylori's ability to establish persistent infection despite host inflammatory responses likely involves active management of host defenses using bacterial proteins that may themselves be targets for adaptive evolution. Sequenced H. pylori genomes encode a family of eight or nine secreted proteins containing repeat motifs that are characteristic of the eukaryotic Sel1 regulatory protein, whereas the related Campylobacter and Wolinella genomes each contain only one or two such "Sel1-like repeat" (SLR) genes ("slr genes"). Signatures of positive selection (ratio of nonsynonymous to synonymous mutations, dN/dS = omega > 1)

SUBMITTER: Ogura M 

PROVIDER: S-EPMC1941758 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature