CSF metabolic and proteomic profiles in patients prodromal for psychosis.

ABSTRACT:

Background

The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period.

Methodology/principal findings

We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first-onset drug naïve paranoid schizophrenia patients (n = 54) and individuals presenting with initial prodromal symptoms (n = 24), alongside healthy volunteers (n = 70) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% o

SUBMITTER: Huang JT 

PROVIDER: S-EPMC1942084 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature