Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

ABSTRACT:

Background

The inflammatory response triggered by cardiac surgery with cardiopulmonary bypass (CPB) is a primary mechanism in the pathogenesis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-patient variability poorly predicted by clinical and procedural factors. We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery.

Methods and results

We genotyped 48 polymorphisms from 23 candidate genes in a prospective cohort of 434 patients undergoing elective cardiac surgery with CPB. PMI was defined as creatine kinase-MB isoenzyme level > or = 10x upper limit of normal at 24 hours postoperatively. A 2-step analysis strategy was used: marker selection, followed b

SUBMITTER: Podgoreanu MV 

PROVIDER: S-EPMC1945056 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature