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ABSTRACT:
SUBMITTER: Gledhill JR
PROVIDER: S-EPMC1948022 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Gledhill Jonathan R JR Montgomery Martin G MG Leslie Andrew G W AG Walker John E JE
Proceedings of the National Academy of Sciences of the United States of America 20070813 34
The structures of F(1)-ATPase from bovine heart mitochondria inhibited with the dietary phytopolyphenol, resveratrol, and with the related polyphenols quercetin and piceatannol have been determined at 2.3-, 2.4- and 2.7-A resolution, respectively. The inhibitors bind to a common site in the inside surface of an annulus made from loops in the three alpha- and three beta-subunits beneath the "crown" of beta-strands in their N-terminal domains. This region of F(1)-ATPase forms a bearing to allow th ...[more]