Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women.

ABSTRACT:

Context

A major determinant of osteoporotic fractures is peak bone mineral density (BMD), which is a highly heritable trait. Recently, we identified significant linkage for hip BMD in premenopausal sister pairs at chromosome 14q (LOD score = 3.5), where the estrogen receptor beta gene (ESR2) is located.

Objective

The objective of the study was to determine whether ESR2 polymorphisms are associated with normal BMD variation.

Design

This was a population-based genetic association study, using 11 single nucleotide polymorphisms (SNPs) distributed across the ESR2 gene.

Setting

The study was conducted at an academic research laboratory and medical center.

Patients and other participants

A total of 411 healthy men (aged 18-61 yr) and 1291 healthy premenopausal

SUBMITTER: Ichikawa S 

PROVIDER: S-EPMC1948071 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature