Ontology highlight
ABSTRACT:
SUBMITTER: Khandelwal A
PROVIDER: S-EPMC1948938 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Khandelwal Abha A Chandu Dilip D Roe Catherine M CM Kopan Raphael R Quatrano Ralph S RS
Proceedings of the National Academy of Sciences of the United States of America 20070807 33
Presenilins (PS) provide the catalytic activity for gamma-secretase, which cleaves physiologically relevant substrates including Notch, ErbB4, and APP. Recent genetic studies indicated that the contribution of PS1 to mouse development includes gamma-secretase-independent functions that cannot be easily explained by any of the demonstrated or hypothesized functions of this protein. To begin a nonbiased analysis of PS1 activity unencumbered by the dominant effect stemming from loss of Notch functi ...[more]