Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells.

ABSTRACT: Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious agents by presenting pathogen-derived antigens on MHC molecules to naïve T cells. Because of their key role in priming adaptive immunity, it is expected that interfering with DC function would be advantageous to the pathogen. We have previously shown that Salmonella enterica serovar Typhimurium (ST), is able to survive inside DCs and interfere with their function by avoiding activation of bacteria-specific T cells. In contrast, when ST is targeted to Fcgamma receptors on the DC surface, bacteria are degraded and their antigens presented to T cells. However, the specific Fcgamma receptor responsible of restoring presentation of antigens remains unknown. Here, we show that IgG-coated ST was targeted

SUBMITTER: Herrada AA 

PROVIDER: S-EPMC1948949 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature