Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis.

ABSTRACT:

Background

Ancient whole genome duplications have been implicated in the vertebrate and teleost radiations, and in the emergence of diverse angiosperm lineages, but the evolutionary response to such a perturbation is still poorly understood. The African clawed frog Xenopus laevis experienced a relatively recent tetraploidization ~40 million years ago. Analysis of the considerable amount of EST sequence available for this species together with the genome sequence of the related diploid Xenopus tropicalis provides a unique opportunity to study the genomic response to whole genome duplication.

Results

We identified 2218 gene triplets in which a single gene in X. tropicalis corresponds to precisely two co-orthologous genes in X. laevis--the largest such collection published from

SUBMITTER: Hellsten U 

PROVIDER: S-EPMC1949811 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature