Lateral motor column axons execute a ternary trajectory choice between limb and body tissues.

ABSTRACT:

Background

Neuronal topographic map formation requires appropriate selection of axonal trajectories at intermediate choice points prior to target innervation. Axons of neurons in the spinal cord lateral motor column (LMC), as defined by a transcription factor code, are thought to innervate limb target tissues exclusively. Axons of the medial and lateral LMC divisions appear to execute a binary decision at the base of the limb as they choose between ventral and dorsal limb trajectories. The cellular logic that guides motor axon trajectory choices into non-limb tissues such as the ventral flank remains unclear.

Results

We determined the spinal cord motor column origin of motor nerves that innervate ventral flank tissues at hindlimb level. We found unexpectedly that a subset of

SUBMITTER: Luria V 

PROVIDER: S-EPMC1949814 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature