The distribution of sexually-transmitted Human Papillomaviruses in HIV positive and negative patients in Zambia, Africa.

ABSTRACT:

Background

Human Papillomaviruses (HPV) are double-stranded DNA viruses, considered to be the primary etiological agents in cervical intraepithelial neoplasias and cancers. Approximately 15-20 of the 40 mucosal HPVs confer a high-risk of progression of lesions to invasive cancer. In this study, we investigated the prevalence of sexually transmitted HPVs in Human Immunodeficiency Virus (HIV) positive and negative patients in Zambia, Africa. The rate of high-risk HPV genotypes worldwide varies within each country. Thus, we sought to investigate the rates of HPV infection in sub-Saharan Africa and the potential role of HIV in affecting the HPV genotype distribution.

Methods

This retrospective cross-sectional study reports findings on the association and effects of HIV on HPV in

SUBMITTER: Ng'andwe C 

PROVIDER: S-EPMC1949816 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature