Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD.

ABSTRACT:

Background

Calcyon is a single transmembrane protein predominantly expressed in the brain. Very recently, calcyon has been implicated in clathrin mediated endocytosis, a critical component of synaptic plasticity. At the genetic level, preliminary evidence supports an association between attention-deficit/hyperactivity disorder (ADHD) and polymorphisms in the calcyon gene. As little is known about the potential role of calcyon in ADHD, animal models may provide important insights into this issue.

Methods

We examined calcyon mRNA expression in the frontal-striatal circuitry of three-, five-, and ten-week-old Spontaneously Hypertensive Rats (SHR), the most commonly used animal model of ADHD, and Wistar-Kyoto (WKY; the strain from which SHR were derived). As a complement, we per

SUBMITTER: Heijtz RD 

PROVIDER: S-EPMC1949817 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature