New complete genome sequences of human rhinoviruses shed light on their phylogeny and genomic features.

ABSTRACT:

Background

Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with enteroviruses and both are part of the picornavirus family. Nevertheless they differ significantly at the phenotypic level. The lack of HRV full-length genome sequences and the absence of analysis comparing picornaviruses at the whole genome level limit our knowledge of the genomic features supporting these differences.

Results

Here we report complete genome sequences of 12 HRV-A and HRV-B serotypes, more than doubling the current number of available HRV sequences. The whole-genome maximum-likelihood phylogenetic analysis suggests that HRV-B and human enterov

SUBMITTER: Tapparel C 

PROVIDER: S-EPMC1949831 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature