Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site.

ABSTRACT:

Background

Transcription factors (TF) regulate expression by binding to specific DNA sequences. A binding event is functional when it affects gene expression. Functionality of a binding site is reflected in conservation of the binding sequence during evolution and in over represented binding in gene groups with coherent biological functions. Functionality is governed by several parameters such as the TF-DNA binding strength, distance of the binding site from the transcription start site (TSS), DNA packing, and more. Understanding how these parameters control functionality of different TFs in different biological contexts is a must for identifying functional TF binding sites and for understanding regulation of transcription.

Methodology/principal findings

We introduce a novel

SUBMITTER: Tabach Y 

PROVIDER: S-EPMC1950076 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature