Detection of a microRNA signal in an in vivo expression set of mRNAs.

ABSTRACT:

Background

microRNAs (miRNAs) are approximately 21 nucleotide non-coding transcripts capable of regulating gene expression. The most widely studied mechanism of regulation involves binding of a miRNA to the target mRNA. As a result, translation of the target mRNA is inhibited and the mRNA may be destabilized. The inhibitory effects of miRNAs have been linked to diverse cellular processes including malignant proliferation, apoptosis, development, differentiation, and metabolic processes. We asked whether endogenous fluctuations in a set of mRNA and miRNA profiles contain correlated changes that are statistically distinguishable from the many other fluctuations in the data set.

Methodology/principal findings

RNA was extracted from 12 human primary brain tumor biopsies. These s

SUBMITTER: Liu T 

PROVIDER: S-EPMC1950084 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature