Transcriptional control in embryonic Drosophila midline guidance assessed through a whole genome approach.

ABSTRACT:

Background

During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands. Many key axon guidance molecules have been identified in both invertebrates and vertebrates, but the transcriptional regulation of growth cone guidance remains largely unknown. It is established that translational regulation plays a role in midline crossing, and there are indications that transcriptional regulation is also involved. To investigate this issue, we conducted a genome-wide study of transcription in Drosophila embryos using wild type and a number of well-characterized Drosophila guidance mutants and transgenics. We also analyzed a previously published microarray time course of Drosophila embryonic devel

SUBMITTER: Magalhaes TR 

PROVIDER: S-EPMC1950096 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature