Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials.

ABSTRACT:

Background

Human papillomavirus (HPV) is now known to be a necessary cause of cervical cancer, and prophylactic HPV vaccines aimed at preventing genital warts, precancerous cervical lesions and cervical cancer are now available. To gauge the potential impact on disease burden, we performed a systematic review of the evidence from randomized controlled trials.

Methods

We conducted a systematic search of the literature to identify all randomized controlled trials of prophylactic HPV vaccination. Reports in 5 electronic databases covering 1950 to June 2007 (MEDLINE, MEDLINE in process, EMBASE, the Cochrane Central Registry of Controlled Trials and the Cochrane Library), bibliographies of all included studies and of narrative reviews (2006-2007), clinical trial registries, Googl

SUBMITTER: Rambout L 

PROVIDER: S-EPMC1950172 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature