Estimating the number needed to vaccinate to prevent diseases and death related to human papillomavirus infection.

ABSTRACT:

Background

A vaccine against human papillomavirus (HPV) types 6, 11, 16 and 18 is now licensed for use in Canada and many other countries. We sought to estimate the number needed to vaccinate to prevent HPV-related diseases and death.

Methods

A cohort model of the natural history of HPV infection was developed. Model simulations were based on 209 different parameter sets that reproduced Canadian HPV type-specific data for infection, cervical intraepithelial neoplasia, cervical cancer and genital warts. The number needed to vaccinate was calculated as the number of women who would need to be vaccinated to prevent an HPV-related event during their lifetime.

Results

Among 12-year-old girls, we estimated that the number needed to vaccinate to prevent an episode of genital

SUBMITTER: Brisson M 

PROVIDER: S-EPMC1950193 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature