Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation.

ABSTRACT:

Background

Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We investigated the role of age in disease incidence and the effects of chemoprophylaxis on clinical immunity development to Plasmodium falciparum during a randomised controlled trial.

Methods and findings

A total of 415 Tanzanian infants were randomly assigned to receive weekly malaria prophylaxis with Deltaprim (3.125 mg of pyrimethamine plus 25 mg of dapsone) or placebo between the ages of 2 and 12 mo. Children were followed up until 4 y of age. Uncomplicated febrile malaria, severe malaria, and anaemia morbidity were assessed thro

SUBMITTER: Aponte JJ 

PROVIDER: S-EPMC1950208 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature