An outbreak of severe infections with community-acquired MRSA carrying the Panton-Valentine leukocidin following vaccination.

ABSTRACT:

Background

Infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination.

Methods and findings

We carried out a field investigation after adverse events following immunization (AEFI) were reported. We reviewed the clinical data from all cases. S. aureus recovered from skin infections and from nasal and throat swabs were analyzed by pulse-field gel electrophoresis, multi locus sequence typing, PCR and microarray. In May 2006, nine children presented with AEFI, ranging from fatal toxic shock syndrome, necrotizing soft tissue infection, purulent abscesses, to fever with rash. All had received a vaccination injection in differe

SUBMITTER: Tang CT 

PROVIDER: S-EPMC1950567 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature