Transposable element dynamics of the hAT element Herves in the human malaria vector Anopheles gambiae s.s.

ABSTRACT: Transposable elements are being considered as genetic drive agents for introducing phenotype-altering genes into populations of vectors of human disease. The dynamics of endogenous elements will assist in predicting the behavior of introduced elements. Transposable element display was used to estimate the site-occupancy frequency distribution of Herves in six populations of Anopheles gambiae s.s. The site-occupancy distribution data suggest that the element has been recently active within the sampled populations. All 218 individuals sampled contained at least one copy of Herves with a mean of 3.6 elements per diploid genome. No significant differences in copy number were observed among populations. Nucleotide polymorphism within the element was high (pi = 0.0079 in noncoding sequences and

SUBMITTER: Subramanian RA 

PROVIDER: S-EPMC1950647 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature