A comparative analysis of the triloops in all high-resolution RNA structures reveals sequence structure relationships.

ABSTRACT: Despite an increasing number of experimentally determined RNA structures, the gap between the number of structures and that of RNA families is still growing. To overcome this limitation, efficient and reliable RNA modeling methodologies must be developed. In order to reach this goal, here, we show how triloop sequence-structure relationships have been inferred through a systematic analysis of all triloops found in available high-resolution structures. The structural annotation of all triloops allowed us to define discrete states of the triloop's conformational space, and therefore an explicit sequence-to-structure relation. The sequence-structure relationships inferred from this explicit relation are presented in a convenient modeling table that provides a limited set of possible three-dim

SUBMITTER: Lisi V 

PROVIDER: S-EPMC1950765 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature