Case-control association testing with related individuals: a more powerful quasi-likelihood score test.

ABSTRACT: We consider the problem of genomewide association testing of a binary trait when some sampled individuals are related, with known relationships. This commonly arises when families sampled for a linkage study are included in an association study. Furthermore, power to detect association with complex traits can be increased when affected individuals with affected relatives are sampled, because they are more likely to carry disease alleles than are randomly sampled affected individuals. With related individuals, correlations among relatives must be taken into account, to ensure validity of the test, and consideration of these correlations can also improve power. We provide new insight into the use of pedigree-based weights to improve power, and we propose a novel test, the MQLS test, which, a

SUBMITTER: Thornton T 

PROVIDER: S-EPMC1950805 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature