Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes.

ABSTRACT: Down syndrome caused by chromosome 21 trisomy is the most common genetic cause of mental retardation in humans. Disruption of the phenotype is thought to be the result of gene-dosage imbalance. Variations in chromosome 21 gene expression in Down syndrome were analyzed in lymphoblastoid cells derived from patients and control individuals. Of the 359 genes and predictions displayed on a specifically designed high-content chromosome 21 microarray, one-third were expressed in lymphoblastoid cells. We performed a mixed-model analysis of variance to find genes that are differentially expressed in Down syndrome independent of sex and interindividual variations. In addition, we identified genes with variations between Down syndrome and control samples that were significantly different from the gen

SUBMITTER: Ait Yahya-Graison E 

PROVIDER: S-EPMC1950826 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature