CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates.

ABSTRACT:

Background

CD4-independence has been taken as a sign of a more open envelope structure that is more accessible to neutralizing antibodies and may confer altered cell tropism. In the present study, we analyzed SIVsm isolates for CD4-independent use of CCR5, mode of CCR5-use and macrophage tropism. The isolates have been collected sequentially from 13 experimentally infected cynomolgus macaques and have previously been shown to use CCR5 together with CD4. Furthermore, viruses obtained early after infection were neutralization sensitive, while neutralization resistance appeared already three months after infection in monkeys with progressive immunodeficiency.

Results

Depending whether isolated early or late in infection, two phenotypes of CD4-independent use of CCR5 could be ob

SUBMITTER: Lauren A 

PROVIDER: S-EPMC1950888 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature