Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.

ABSTRACT: Recently, the relationship of mitochondrial DNA (mtDNA) variants to metabolic risk factors for diabetes and other common diseases has begun to attract increasing attention. However, progress in this area has been limited because (1) the phenotypic effects of variation in the mitochondrial genome are difficult to isolate owing to confounding variation in the nuclear genome, imprinting phenomena, and environmental factors; and (2) few animal models have been available for directly investigating the effects of mtDNA variants on complex metabolic phenotypes in vivo. Substitution of different mitochondrial genomes on the same nuclear genetic background in conplastic strains provides a way to unambiguously isolate effects of the mitochondrial genome on complex traits. Here we show that conplasti

SUBMITTER: Pravenec M 

PROVIDER: S-EPMC1950900 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature