Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex.

ABSTRACT: Interneurons originating from the ganglionic eminence migrate tangentially into the developing cerebral wall as they navigate to their distinct positions in the cerebral cortex. Compromised connectivity and differentiation of interneurons are thought to be an underlying cause in the emergence of neurodevelopmental disorders such as schizophrenia. Previously, it was suggested that tangential migration of interneurons occurs in a radial glia independent manner. Here, using simultaneous imaging of genetically defined populations of interneurons and radial glia, we demonstrate that dynamic interactions with radial glia can potentially influence the trajectory of interneuronal migration and thus the positioning of interneurons in cerebral cortex. Furthermore, there is extensive local interneuro

SUBMITTER: Yokota Y 

PROVIDER: S-EPMC1950908 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature