Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays.

ABSTRACT: Genomic aberrations recurrent in a particular cancer type can be important prognostic markers for tumor progression. Typically in early tumorigenesis, cells incur a breakdown of the DNA replication machinery that results in an accumulation of genomic aberrations in the form of duplications, deletions, translocations, and other genomic alterations. Microarray methods allow for finer mapping of these aberrations than has previously been possible; however, data processing and analysis methods have not taken full advantage of this higher resolution. Attention has primarily been given to analysis on the single sample level, where multiple adjacent probes are necessarily used as replicates for the local region containing their target sequences. However, regions of concordant aberration can be sh

SUBMITTER: Guttman M 

PROVIDER: S-EPMC1950957 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature