Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.

ABSTRACT:

Background

Type 2 diabetes arises when insulin resistance-induced compensatory insulin secretion exhausts. Insulin resistance and/or beta-cell dysfunction result from the interaction of environmental factors (high-caloric diet and reduced physical activity) with a predisposing polygenic background. Very recently, genetic variations within four novel genetic loci (SLC30A8, HHEX, EXT2, and LOC387761) were reported to be more frequent in subjects with type 2 diabetes than in healthy controls. However, associations of these variations with insulin resistance and/or beta-cell dysfunction were not assessed.

Methodology/principal findings

By genotyping of 921 metabolically characterized German subjects for the reported candidate single nucleotide polymorphisms (SNPs), we show that

SUBMITTER: Staiger H 

PROVIDER: S-EPMC1952072 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature