Human immunity and the design of multi-component, single target vaccines.

ABSTRACT:

Background

Inclusion of multiple immunogens to target a single organism is a strategy being pursued for many experimental vaccines, especially where it is difficult to generate a strongly protective response from a single immunogen. Although there are many human vaccines that contain multiple defined immunogens, in almost every case each component targets a different pathogen. As a consequence, there is little practical experience for deciding where the increased complexity of vaccines with multiple defined immunogens vaccines targeting single pathogens will be justifiable.

Methodology/principal findings

A mathematical model, with immunogenicity parameters derived from a database of human responses to established vaccines, was used to predict the increase in the efficacy and

SUBMITTER: Saul A 

PROVIDER: S-EPMC1952173 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature