Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women.

ABSTRACT:

Background

Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular disease in women without diabetes is unclear. Our aim was to determine the independent associations of fasting insulin, glucose, and glycated haemoglobin with coronary heart disease and stroke in older women.

Methods and findings

We undertook a prospective cohort study of 3,246 British women aged 60-79 y, all of whom were free of baseline coronary heart disease, stroke, and diabetes, and all of whom had fasting glucose levels below 7 mmol/l. Fasting insulin and

SUBMITTER: Lawlor DA 

PROVIDER: S-EPMC1952205 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature