Structure of Citrobacter freundii L-methionine gamma-lyase.

ABSTRACT: L-Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catalyzes gamma-elimination of L-methionine. The crystal structure of MGL from Citrobacter freundii has been determined at 1.9 A resolution. The spatial fold of the protein is similar to those of MGLs from Pseudomonas putida and Trichomonas vaginalis. The comparison of these structures revealed that there are differences in PLP-binding residues and positioning of the surrounding flexible loops.

SUBMITTER: Mamaeva DV 

PROVIDER: S-EPMC1952331 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature