Ectopic lymphoid neogenesis in psoriatic arthritis.

ABSTRACT:

Background

Ectopic lymphoid neogenesis (LN) occurs in rheumatoid synovium, where it is thought to drive local antigen-dependent B cell development and autoantibody production. This process involves the expression of specific homing chemokines and the development of high endothelial venules (HEV).

Objective

To investigate whether these mechanisms occur in psoriatic arthritis (PsA) synovium, where autoantibodies have not been described and the organisation and function of B cells is not clear, and to analyse their clinical correlates.

Methods

Arthroscopic synovial biopsy specimens from patients with PsA before and after tumour necrosis factor alpha blockade were characterised by immunohistochemical analysis for T/B cell segregation, peripheral lymph node addressin (PNAd

SUBMITTER: Canete JD 

PROVIDER: S-EPMC1954653 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature