Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis.

ABSTRACT:

Objective

To replicate the association of frizzled-related protein (FRZB) non-synonymous polymorphisms with osteoarthritis (OA) susceptibility.

Methods

Three groups of Spanish patients with OA were included: with total joint replacement due to primary OA in the hip (n = 310), or the knee (n = 277), or with hand OA (n = 242). Controls were more than 55 years old and did not show OA (n = 294). SNPs rs288326 (R200W) and rs7775 (R324G) were genotyped.

Results

There were no significant differences in allele frequencies between controls and each of the three groups of OA patients. However, allele G of the R324G SNP showed a trend to be more frequent in patients with a clinical OA syndrome at multiple joints (p = 0.07), specifically in women of the total hip replacement grou

SUBMITTER: Rodriguez-Lopez J 

PROVIDER: S-EPMC1954696 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature