Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a heterogeneous disease with unknown cause.

Aim

To identify peripheral blood (PB) gene expression profiles that may distinguish RA subtypes.

Methods

Large-scale expression profiling by cDNA microarrays was performed on PB from 35 patients and 15 healthy individuals. Differential gene expression was analysed by significance analysis of microarrays (SAM), followed by gene ontology analysis of the significant genes. Gene set enrichment analysis was applied to identify pathways relevant to disease.

Results

A substantially raised expression of a spectrum of genes involved in immune defence was found in the PB of patients with RA compared with healthy individuals. SAM analysis revealed a highly significant elevated expression o

SUBMITTER: van der Pouw Kraan TC 

PROVIDER: S-EPMC1954704 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature