Assessment of the contribution of CFH and chromosome 10q26 AMD susceptibility loci in a Russian population isolate.

ABSTRACT:

Background/aims

A strong association has been confirmed between age-related macular degeneration (AMD) and variants at two independent loci including Tyr402His in the complement factor H (CFH) on 1q32 and Ser69Ala at LOC387715, a hypothetical gene on chromosome 10q26. The contribution of both loci to AMD was investigated in an isolated north-west Russian population.

Methods

Together with a PLEKHA1 variant at 10q26, the CFH Tyr402His and LOC387715 Ser69Ala polymorphisms were genotyped in 155 patients with AMD and 151 age-matched controls. chi(2) and Mantel-Haenszel (M-H) score tests were used to test for association. Sex-adjusted ORs were calculated.

Results

The frequency of the Tyr402His C allele was significantly higher in patients with AMD compared with controls (p(

SUBMITTER: Fisher SA 

PROVIDER: S-EPMC1954757 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature