Cia25 on rat chromosome 12 regulates severity of autoimmune arthritis induced with pristane and with collagen.

ABSTRACT:

Background

A genomewide scan in a DA x ACI F2 intercross studied for collagen-induced arthritis (CIA) identified the severity quantitative trait locus Cia25 on rat chromosome 12. Cia25 co-localises with loci regulating several forms of autoimmune diseases in rats, mice and humans, suggesting a common gene.

Objective

To characterise the effects of Cia25 on severity of arthritis in congenic rats.

Methods

DA.ACI(Cia25) congenic rats were constructed according to a genotype-guided strategy, and tested for pristane-induced arthritis (PIA) and CIA, induced with rat type II collagen (CII). A well-established scoring system previously shown to correlate with histological damage, including cartilage and bone erosions, synovial hyperplasia and synovial inflammation, was used.

SUBMITTER: Brenner M 

PROVIDER: S-EPMC1955106 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature