Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial.

ABSTRACT:

Objective

To compare the efficacy of oral antibiotic treatment alone with treatment started parenterally and completed orally in children with a first episode of acute pyelonephritis.

Design

Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial.

Setting

28 paediatric units in north east Italy.

Participants

502 children aged 1 month to <7 years with clinical pyelonephritis.

Intervention

Oral co-amoxiclav (50 mg/kg/day in three doses for 10 days) or parenteral ceftriaxone (50 mg/kg/day in a single parenteral dose) for three days, followed by oral co-amoxiclav (50 mg/kg/day in three divided doses for seven days). Main outcomes measures Primary outcome was the rate of renal scarring. Secondary measures of efficacy were time

SUBMITTER: Montini G 

PROVIDER: S-EPMC1955287 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature