Overexpressed TP73 induces apoptosis in medulloblastoma.

ABSTRACT:

Background

Medulloblastoma is the most common malignant brain tumor of childhood. Children who relapse usually die of their disease, which reflects resistance to radiation and/or chemotherapy. Improvements in outcome require a better understanding of the molecular basis of medulloblastoma growth and treatment response. TP73 is a member of the TP53 tumor suppressor gene family that has been found to be overexpressed in a variety of tumors and mediates apoptotic responses to genotoxic stress. In this study, we assessed expression of TP73 RNA species in patient tumor specimens and in medulloblastoma cell lines, and manipulated expression of full-length TAp73 and amino-terminal truncated DeltaNp73 to assess their effects on growth.

Methods

We analyzed medulloblastoma samples fro

SUBMITTER: Castellino RC 

PROVIDER: S-EPMC1955450 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature