SNPs in the FOXP3 gene region show no association with Juvenile Idiopathic Arthritis in a UK Caucasian population.

ABSTRACT:

Objective

A region on the short arm of the X-chromosome, Xp11, has previously been linked to childhood-onset polyarthritis. Mapping to the linked region is FOXP3, a transcription factor that regulates regulatory T cell (T(reg)) development and function. The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in the FOXP3 gene region contribute to JIA susceptibility.

Method

Nine FOXP3 SNPs were genotyped in 761 JIA cases and 402 controls using the Sequenom MassARRAY system. Association was measured using either chi(2) or Fisher's exact test at the allelic and genotypic level. Furthermore, cases and controls were stratified by gender and association measured for each stratum.

Results

None of the SNPs showed an association with JIA. Si

SUBMITTER: Eastell T 

PROVIDER: S-EPMC1955685 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature