The H19 non-coding RNA is essential for human tumor growth.

ABSTRACT:

Background

Mutations and epigenetic aberrant signaling of growth factors pathways contribute to carcinogenesis. Recent studies reveal that non-coding RNAs are controllers of gene expression. H19 is an imprinted gene that demonstrates maternal monoallelic expression without a protein product; although its expression is shut off in most tissues postnatally, it is re-activated during adult tissue regeneration and tumorigenesis. Moreover, H19 is highly expressed in liver metastasis derived from a range of carcinomas. The objective of this study is to explore the role of H19 in carcinogenesis, and to determine its identification as an anti-tumor target.

Methodology/principle findings

By controlling oxygen pressure during tumor cell growth and H19 expression levels, we investigate

SUBMITTER: Matouk IJ 

PROVIDER: S-EPMC1959184 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature