Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage.

ABSTRACT: Interleukin (IL)-1 is one of the most important catabolic cytokines in rheumatoid arthritis. In this study, we were interested in whether we could identify IL-1 expression and activity within normal and osteoarthritic cartilage. mRNA expression of IL-1beta and of one of its major target genes, IL-6, was observed at very low levels in normal cartilage, whereas only a minor up-regulation of these cytokines was noted in osteoarthritic cartilage, suggesting that IL-1 signaling is not a major event in osteoarthritis. However, immunolocalization of central mediators involved in IL-1 signaling pathways [38-kd protein kinases, phospho (P)-38-kd protein kinases, extracellular signal-regulated kinase 1/2, P-extracellular signal-regulated kinase 1/2, c-Jun NH(2)-terminal kinase 1/2, P-c-Jun NH(2)-ter

SUBMITTER: Fan Z 

PROVIDER: S-EPMC1959501 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature