Effect of antibiotic prescribing on antibiotic resistance in individual children in primary care: prospective cohort study.

ABSTRACT:

Objective

To assess the effect of community prescribing of an antibiotic for acute respiratory infection on the prevalence of antibiotic resistant bacteria in an individual child.

Study design

Observational cohort study with follow-up at two and 12 weeks.

Setting

General practices in Oxfordshire.

Participants

119 children with acute respiratory tract infection, of whom 71 received a beta lactam antibiotic.

Main outcome measures

Antibiotic resistance was assessed by the geometric mean minimum inhibitory concentration (MIC) for ampicillin and presence of the ICEHin1056 resistance element in up to four isolates of Haemophilus species recovered from throat swabs at recruitment, two weeks, and 12 weeks.

Results

Prescribing amoxicillin to a child in gen

SUBMITTER: Chung A 

PROVIDER: S-EPMC1962897 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature