Metabolome based reaction graphs of M. tuberculosis and M. leprae: a comparative network analysis.

ABSTRACT:

Background

Several types of networks, such as transcriptional, metabolic or protein-protein interaction networks of various organisms have been constructed, that have provided a variety of insights into metabolism and regulation. Here, we seek to exploit the reaction-based networks of three organisms for comparative genomics. We use concepts from spectral graph theory to systematically determine how differences in basic metabolism of organisms are reflected at the systems level and in the overall topological structures of their metabolic networks.

Methodology/principal findings

Metabolome-based reaction networks of Mycobacterium tuberculosis, Mycobacterium leprae and Escherichia coli have been constructed based on the KEGG LIGAND database, followed by graph spectral analysis

SUBMITTER: Verkhedkar KD 

PROVIDER: S-EPMC1964534 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature