Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy.

ABSTRACT:

Background

The Down syndrome phenotype has been attributed to overexpression of chromosome 21 (Hsa21) genes. However, the expression profile of Hsa21 genes in trisomic human subjects as well as their effects on genes located on different chromosomes are largely unknown. Using oligonucleotide microarrays we compared the gene expression profiles of hearts of human fetuses with and without Hsa21 trisomy.

Results

Approximately half of the 15,000 genes examined (87 of the 168 genes on Hsa21) were expressed in the heart at 18-22 weeks of gestation. Hsa21 gene expression was globally upregulated 1.5 fold in trisomic samples. However, not all genes were equally dysregulated and 25 genes were not upregulated at all. Genes located on other chromosomes were also significantly dysregula

SUBMITTER: Conti A 

PROVIDER: S-EPMC1964766 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature